Andrew Cole, MD, FRCP (Chair)

Massachusetts General Hospital, Harvard Medical School

Andrew J. Cole, MD, FRCP(C), is Professor of Neurology at Harvard Medical School and Vice-Chair of the Department of Neurology, Chief of the Division of Clinical Neurophysiology, and  Director of the MGH Epilepsy Service and Research Laboratory at Massachusetts General Hospital in Boston. Dr. Cole also directs the Epilepsy and Clinical Neurophysiology Fellowship Programs at MGH. Dr. Cole graduated magna cum laude from Dartmouth College in Hanover, New Hampshire, and obtained his medical degree from Dartmouth Medical School. He completed an internship in internal medicine at Case Western Reserve University in Cleveland, Ohio, and a residency and chief residency in neurology at the Montreal Neurological Institute, McGill University, Montreal, Quebec. Dr. Cole was Chief Fellow in the Laboratory of Clinical Neurophysiology and Electroencephalography at Montreal Neurological Institute, and then a research fellow at the Department of Neuroscience at Johns Hopkins University School of Medicine in Baltimore, Maryland. He served as Assistant Professor of Neurology at Johns Hopkins in Baltimore before moving to Massachusetts General Hospital where he has been since 1992. At MGH he oversees a large Epilepsy Clinic, a busy Epilepsy Surgery Program, and an Epilepsy and Clinical Neurophysiology Fellowship program that has trained over 90 fellows under his directorship. He has had NIH funding to support basic research on the consequences of abnormal neuronal activity, and he has been a Principle Investigator on numerous NIH and industry supported clinical trials of drugs and devices in epilepsy. He was the Founding Chair of the American Epilepsy Society Translational Research Committee and has been a member of the AES Program Committee and the AES Research and Training Committee. He chaired the American Epilepsy Society’s Annual Course Committee and was Director of the AES Annual Course from 2002 through 2004.  He is the Founding Associate Editor of Annals Clinical and Translational Neurology and has been a member of the Editorial Boards of Epilepsia and Neurology and Clinical Neurophysiology. He serves as an ad hoc reviewer for many journals, including Science, Neurology, the New England Journal of Medicine, Annals of Neurology, Archives of Neurology, Epilepsy Research, Neuropharmacology and the Journal of Neuroscience. He has authored and coauthored over 150 papers, chapters and abstracts on epilepsy and cellular and molecular correlates of neuronal activity and has been an organizer, discussant or invited speaker at many national and international meetings. In the field of epilepsy he is considered expert in the evaluation and surgical treatment of patients with refractory epilepsy. He is credited with focusing attention on the role of immediate early gene expression after seizures and in association with synaptic plasticity, developing the “two-hit” hypothesis of epileptogenesis, identifying a role for Nerve Growth Factor Receptor-bearing neurons in protecting against seizure-induced neuronal injury during development, improving the application of modern neuroimaging tools, including high field strength anatomic scanning and peri-ictal imaging, in patient care, and advancing the surgical treatment of highly refractory focal status epilepticus. In recent years he led the first implantation of a responsive neurostimulator into the thalamus of a patient with drug resistant idiopathic generalized epilepsy, administered the first-in-man treatment with allopregnanalone in refractory status epilepticus, and described the occurrence of silent seizures in the hippocampus of patients with Alzheimer’s Disease.