What Type Of Evidence Should Drive Clinical Decision-Making?

Date/Time: Thursday, October 8, 2020 - 12:30 PM – 1:45 PM
Track: Interactive Workshop
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Clinical decisions need to be fueled by solid data. Until recently, this was translated to mean that well conducted randomized controlled trials (RCTs) or meta-analyses that derive from them should be the primary source of data for all "evidence based" guidelines. However, recently there is more discussion regarding the biases that can be introduced by RCT's with excellent methodology but limited generalizability. This symposium will use examples derived from several neurologic conditions to address the contribution of RCTs vs other forms of data to clinical decision-making


Can Observational Studies Ever Support Strong Guideline Recommendations?

Can the Endpoints Measured in Clinical Trials Capture Clinical Meaningfulness?

Statistical Approaches to the Analysis of Data and limitations

When RCTs and Real World Evidence Disagree: What Do We Believe?