Microenvironment Control of Brain Tumor Pathogenesis

Date/Time: Monday, October 5, 2020 - 3:30 PM – 5:30 PM
Track: Plenary Session
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Description:

Brain tumors are complex cellular ecosystems composed of both neoplastic and non-neoplastic cell types. While considerable research has focused on the genetics, genomics, and growth control pathways operative in the cancer cells, there has been comparatively less focus on the non-neoplastic cells. This session will focus on recent findings that non-neoplastic cells in the brain, including neurons, microglia, and T cells, regulate brain tumor formation and progression, as well as metastasis to the brain. Moreover, each of these cellular dependencies represent opportunities for targeted therapies against tumors of the central nervous system.

Objective(s):

  • To understand that neurons in the tumor microenvironment are critical drivers of brain tumor formation and growth.

  • To understand that immune system cells in the tumor microenvironment are critical drivers of brain tumor formation and growth.

  • To understand that immune system cells represent therapeutic vehicles for the treatment of brain tumors.

Speaker(s):

Immune System Cell Regulation of Brain Tumor Pathobiology


Neuronal Regulation of Brain Tumor Pathobiology


Self-organization of the Microenvironment Determines Glioma Pathogenesis


The Brain Microenvironment and Metastasis