Microenvironment Control of Brain Tumor Pathogenesis

Date/Time: Monday, October 5, 2020 - 12:45 PM – 2:45 PM
Track: Plenary Session
Room: San Francisco
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Description:

Brain tumors are complex cellular ecosystems composed of both neoplastic and non-neoplastic cell types. While considerable research has focused on the genetics, genomics, and growth control pathways operative in the cancer cells, there has been comparatively less focus on the non-neoplastic cells. This session will focus on recent findings that non-neoplastic cells in the brain, including neurons, microglia, and T cells, regulate brain tumor formation and progression, as well as metastasis to the brain. Moreover, each of these cellular dependencies represent opportunities for targeted therapies against tumors of the central nervous system.

Chair: Steven Small, MD, PhD, University of Texas at Dallas
Co-Chair: David Gutmann, MD, PhD, FAAN, Washington University in St. Louis 

Objective(s):

  • Understand that immune system cells in the tumor microenvironment are critical drivers of brain tumor formation and growth

  • Understand that immune system cells represent therapeutic vehicles for the treatment of brain tumors

  • Understand that immune system cells represent therapeutic vehicles for the treatment of brain tumors 

Speaker(s):

Immune System Cell Regulation of Brain Tumor Pathobiology


Immunotherapy for Brain Tumors


Neuronal Regulation of Brain Tumor Pathobiology


The Brain Microenvironment and Metastasis